August 21, 2025
Colorectal cancer is the second leading cause of cancer-related deaths for both men and women in the United States and is largely preventable with regular screenings starting at age 45.1 While the overall incidence of this disease has been declining in older populations – thanks in large part to widespread screening and changes in lifestyle – rates are unfortunately on the rise in younger adults. Currently, an average of 54 new cases are diagnosed each day in individuals aged 50 or younger.2
Your proactive screening guidance has the power to save lives
Patients of all ages are increasingly seeking information about colorectal cancer symptoms and screening options for colorectal cancer. As a trusted health care provider, your recommendation can be a crucial motivator for them to take action.
Empowering patients through education and screening
Strategies for effective patient communication
Health care providers are encouraged to discuss colorectal cancer risks and screening options, even with patients younger than the current screening recommendation of age 45. Research indicates that emphasizing the importance and benefits of screening, addressing patient concerns, and explaining available screening options, are effective strategies.4
Here are some suggested approaches for these important conversations:4 5
2025 HEDIS updates related to colorectal cancer
For the Healthcare Effectiveness Data and Information Set (HEDIS®)6 2025 measurement year, only electronic clinical data reporting will be used for the colon cancer screening measure.7
Colorectal cancer screening coverage
Colorectal cancers screenings are typically covered at no cost to your patients with Cigna Healthcare® coverage when performed at in-network locations, which they can find by logging in to myCigna.com.
You can find more information on Cigna Healthcare preventive care services in the Preventive Care Services Coverage Policy (A004).
Colorectal cancer screening codes
The table below shows the different screening options, their recommended frequencies, and corresponding Current Procedural Terminology (CPT®) codes to use.
Test | Frequency2 | CPT code |
Colonoscopy | Every ten years. | 44388–44392, 44394, 44401–44408, 45378–45382, 45384–45386, 45388–45393, and 45398. |
Computed tomography colonography | Every five years. | 74261–74263. |
Stool DNA test with fecal immunochemical test (e.g., Cologuard®) | Every one to three years. | 81528 |
Fecal occult blood test (e.g., InSure® ONE, ColoFIT®) | Every year. | 82270 and 82274. |
Flexible sigmoidoscopy | Every five years. | 45330–45335, 45337–45338, 45340–45342, 45346–45347, and 45349–45350. |
1 Colorectal Cancer: Screening.
2 Colorectal Cancer Facts & Figures 2023.
3 Colorectal Cancer Risk Factors 2023-2025.
4 Lead-Time-Messaging-Guidebook: A tool to Encourage On-Time Colorectal Cancer Screening.
5 Colorectal Cancer Screening: Conversation Starters.
6 HEDIS® is a registered trademark of the National Committee for Quality Assurance (NCQA).
7 HEDIS MY 2024: What’s New, What’s Changed, What’s Retired.
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