Cigna Pathwell Specialty: Changes to the drug list

December 11, 2025

Cigna Pathwell Specialty® is for patients using a specialty medication to treat a complex medical condition. As part of this in-network-only benefit plan option, certain medications must be administered by a Cigna Pathwell Specialty designated provider or ordered from Cigna Pathwell Specialty designated pharmacy to be covered.

Cigna Healthcare® will expand the Cigna Pathwell Specialty Drug List to include the following:

NameDate added
ZIIHERA®April 21, 2025
BAVENCIO®July 1, 2025
CLADRIBINE®July 1, 2025
COSMEGEN®July 1, 2025
VIDAZA®July 1, 2025
NIPENT®July 1, 2025
POLIVY®July 1, 2025
ZALTRAP®July 1, 2025
ARRANON®July 1, 2025
Yimmugo® (immune globulin intravenous, human-dira)November 17, 2025
Keytruda QlexTM (pembrolizumab and berahyaluronidase alfa-pmph)November 17, 2025
Tyruko® (natalizumab-sztn)November 17, 2025
Bildyos® (denosumab-nxxp)November 17, 2025
Avtozma® (tocilizumab)November 17, 2025
InlexzoTM (gemcitabine intravesical system)November 17, 2025
Bilprevda® (denosumab-nxxp)November 17, 2025
Papzimeos (zopapogene imadenovec-drba)November 17, 2025
UnloxcytTM (cosibelimab-ipdl)November 17, 2025
Jobevne (bevacizumab-nwgd)November 17, 2025
Blenrep® (belantamab mafodotin-blmf)November 17, 2025

The following drugs were removed from the Cigna Pathwell Specialty Drug List:

NameEffective Date
Alimta (pemetexed disodium)November 17, 2025
Cimzia® (certolizumab pegol)November 17, 2025
Procrit®/Epogen® (epoetin alpha)  November 17, 2025

What this means

Patients with the Cigna Pathwell Specialty option who require a drug on the Cigna Pathwell Specialty list must have the drug administered by a Cigna Pathwell Specialty Network–participating provider. This will help ensure patients receive the maximum benefit coverage. Although there are no out-of-network benefits, there are times when a drug may be covered without moving a patient with Cigna Healthcare coverage to another infusion facility or provider; however, these exceptions are reviewed on a case-by-case basis.

To find a provider who participates in the Cigna Pathwell Specialty Network, visit Cigna.com and follow these steps to search the provider directory:

  1. Select Employer or School.
  2. Enter your geographic location.
  3. Click Doctor by Type.
  4. Type Pathwell Specialty.
  5. Click Search.
  6. Click Continue as guest.
  7. After completing the requested information, providers who participate in the Cigna Pathwell Specialty Network will appear. (Note: Results may appear after clicking Search at step 5.

Additional information

The most current Cigna Pathwell Specialty Drug List is available on the Cigna for Health Care Professionals website (CignaforHCP.com). Please check this list often as it is updated periodically.

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